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Updated: Feb 23, 2026

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
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盲目から結合へ：CRISPRは患者TregのIL-2応答性を回復させる

Andrew D Brim1, Leonardo M R Ferreira1

  • 1Department of Pharmacology and Immunology, Medical University of South Carolina, Charleston, SC, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.

Molecular therapy : the journal of the American Society of Gene Therapy
|February 21, 2026
PubMed
まとめ

No abstract available in PubMed .

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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