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Updated: Feb 23, 2026

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
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青少年におけるストレス感受性およびうつ病再発の周期的なサイン

Mikki Schantell1, Nayoung Kim1, Esha Trivedi1

  • 1Department of Psychiatry, Columbia University, New York, New York; Division of Child & Adolescent Psychiatry, New York State Psychiatric Institute, New York, New York.

Biological psychiatry. Cognitive neuroscience and neuroimaging
|February 21, 2026
PubMed
まとめ

思春期の脳活動における無周期的な傾きは,重度のうつ病 (MDD) の再発を予測する可能性がある. 平らな斜面は,低ストレス下では再発から保護しますが,高ストレス下ではリスクを高め,ダイアテシス-ストレスモデルを示唆します.

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