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Updated: Feb 23, 2026

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5α-reductase (SRD5A2) の活性に干渉するキセノバイオティクスの特定

Jacek Kędzierski1, Rianne E van Diest1, Julien A Allard2

  • 1Computational Pharmacy, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, Basel, 4056, Switzerland; Swiss Centre for Applied Human Toxicology, University of Basel, Missionsstrasse 64, Basel, 4055, Switzerland.

Toxicology letters
|February 21, 2026
PubMed
まとめ

この研究では,男性発育に不可欠な酵素であるステロイド5α-還元酵素2型 (SRD5A2) の阻害剤を見つけるための計算方法を開発しました. アンドロゲン受容体調節剤MK-0773は,適度なSRD5A2阻害剤として特定されました.

キーワード:
コンセンサス・ドッキングディヒドロキシテストステロンSRD5A2は,SRD5A2に記載されています.ステロイド代謝 ステロイド代謝仮想スクリーニング

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