関連する実験動画

Updated: Feb 23, 2026

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
06:48

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Published on: January 5, 2024

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バイオ分子凝縮物におけるアロステリック薬:将来への道

Ruth Nussinov1, Clil Regev2, Hyunbum Jang3

  • 1Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA; Cancer Innovation Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Drug discovery today
|February 21, 2026
PubMed
まとめ

病気において重要なバイオマクロモレキュラー凝縮物は,新しいアロステル薬の標的となっている. この研究は,濃縮物に適応した,タンパク質特異的な薬物の発見を,治療の可能性を高めるために探求しています.

キーワード:
アロステリー (allostery) とは形状の変化 形状の変化コンフォーマーションアンサンブルは,コンフォーマーションアンサンブルである.協調性は,協調性である.阻害剤を抑制する.膜のないバイオマクロ分子コンデンサート

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