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Updated: Feb 23, 2026

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
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A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli

Published on: December 9, 2017

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非水解性アセチリシンの類型は,タンパク質アセチル化を研究するためにインビトロおよび細胞内で行われます

Simon Maria Kienle1,2, Matthias Sigg3, Tobias Schneider4,5

  • 1Department of Biology, University of Konstanz, Konstanz, Germany. simon.kienle@uni-konstanz.de.

Nature communications
|February 21, 2026
PubMed
まとめ

ケトリシン (KeK) はアセチリシン (AcK) の安定したアナログであり,AcKの効果を模倣する. KeKをp53のようなタンパク質に組み込むことは,細胞におけるアセチル化の機能的結果の安定した,サイト特異的な研究を可能にします.

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