関連する実験動画

Updated: Feb 23, 2026

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

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RORγt+ APCは,食事による抗原に対する耐性を指示するために,異なるシス調節要素を必要とします

Jie Zhao1,2,3,4, Jiacheng Hao1,2,3,4, Jincheng Chen1,2,3,4

  • 1Institute for Immunology, Tsinghua University, Beijing, China.

Nature communications
|February 21, 2026
PubMed
まとめ

新たに特定された規制要素であるOCR369は,抗原呈現細胞 (APC) でのRORγt発現を制御しており,これは経口での耐性にとって極めて重要です. その消去はTregの発達を阻害し,腸の炎症を引き起こし,アレルギーの感受性を高めます.

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