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Updated: Feb 23, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
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DNMT2は,5'tiRNAGly-GCCの産生をダウンレギュレーションすることによって,アナプラスティック甲状腺がんの進行を抑制する

Ruixin Zhou1,2, Baizhao Li1,2, Mingyu Cao1,2

  • 1Department of General Surgery, Xiangya Hospital of Central South University, Changsha, Hunan, China.

Cell death & disease
|February 21, 2026
PubMed
まとめ

減少したDNAメチルトランスフェラーゼ2 (DNMT2) 発現は,5'tiRNAGly-GCCを増加させることで,アナプラスティック甲状腺癌 (ATC) を促進する. この分子は hnRNPH1 を標的とし,腫瘍の進行を促します. 5'tiRNAGly-GCCを阻害することは,ATCの治療の可能性を示しています.

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