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Updated: Feb 23, 2026

Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran
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Published on: November 18, 2022

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老化によって引き起こされる腸内微生物群の変化は,腸内バリア機能不全を引き起こし,敗血症の感受性を高めます

Huoyan Liang1, Xianfei Ding1, Shaohua Liu1

  • 1Department of Critical Care Medicine, Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Henan Engineering Research Center for Critical Care Medicine, Henan Key Laboratory of Critical Care Medicine, Henan Key Laboratory of Sepsis in Health Commission, Zhengzhou Key Laboratory of Sepsis, Henan Sepsis Diagnosis and Treatment Center, Zhengzhou, People's Republic of China.

Gut microbes
|February 21, 2026
PubMed
まとめ

老化は,ヒスタミン (HA) を産生するクレブシエラ・エアロゲネスを増加させることにより,セプシスを悪化させる. このヒスタミンは,Nlrp6-LC3経路を妨害することで,腸内バリア機能を低下させ,HA-Nlrp6-LC3軸が高齢者のセプシスの治療標的であることを示唆しています.

キーワード:
K. アエロ アエロ アエロセプシス・セプシスとは老化,老化は,老化しています.ヒスタミンヒスタミンは,腸内障壁の機能不全が起きている.

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