関連する実験動画

Updated: Feb 24, 2026

Quantifying Agonist Activity at G Protein-coupled Receptors
11:45

Quantifying Agonist Activity at G Protein-coupled Receptors

Published on: December 26, 2011

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新しい潜在的なPPARαアゴニストの設計,合成,および活動評価

Xiaoqian Wang1, Weinan Wang2, Jixuan Guo3

  • 1School of Chemical Engineering, Sichuan University of Science & Engineering, Zigong 643000, China; Zhejiang Key Laboratory of Intelligent Drug Discovery and Development, School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, UCAS, Hangzhou 310024, China.

Bioorganic & medicinal chemistry
|February 22, 2026
PubMed
まとめ

研究者らは,代謝疾患の治療のためにペロキシソーム増殖器活性化受容体α (PPARα) を標的とする新しい化合物を特定しました. 化合物GJX-230は高い活性を示し,HMGCS2を上昇調節し,より安全なPPARαアゴニストの開発の可能性を提供しました.

キーワード:
ドラッグデザイン ドラッグデザインPPARαアゴニストである.構造変化による構造変化シンセシス シンセシス

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