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Updated: Feb 24, 2026

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
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低用量製剤の連続ツインスクルー湿粒化:プロセス変数とAPI/結合剤添加方法が粒子の品質属性に与える影響

Louis Bouckaert1, Mathieu Ombecq1, Giorgia Adamo1

  • 1Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.

International journal of pharmaceutics
|February 22, 2026
PubMed
まとめ

低用量薬のツインスクルー湿粒化 (TSWG) を最適化することは極めて重要です. 高い液体/固体比率と回転速度は,APIの濡れやすさに問題があるにもかかわらず,粒子のサイズとAPIの均一性を改善します.

キーワード:
API/バインダー添加方法区分分析とは,区分分析である.連続した製造製造.実験のデザイン低用量製剤による低用量製剤です.ツインスクルーのウェットグラニュレーション絶対偏差の加重平均値から

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