関連する実験動画

Updated: Feb 24, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

9.6K

Gタンパク質結合時に活性化されたドーパミン受容体におけるアロステリック制御と水によるシグナル伝達

Xing-Yan Lai1, Chun-Chun Chang2, Hao-Jen Hsu3

  • 1Institute of Medical Sciences, College of Medicine, Tzu Chi University, Hualien, 97004, Taiwan.

International journal of biological macromolecules
|February 22, 2026
PubMed
まとめ

分子ダイナミクスシミュレーションにより,ドーパミン受容体 (DRs) がマイクロスイッチや水路ネットワークを通じてどのように活性化されるかが明らかになりました. これは,神経学的障害に対するリガンド特異的なシグナル伝達と薬物設計に関する洞察を提供します.

キーワード:
ドーパミン受容体はドーパミンの受容体です.Gタンパク質結合受容体は,Gタンパク質結合受容体である.分子ダイナミクスシミュレーション分子スイッチである分子スイッチ.

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