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Updated: Feb 24, 2026

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
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GNE-493は,HK2のNAT10媒介のac4C変異をターゲットにすることで,胃がんの発症を抑制する

Tengkai Wang1, Junling Zhen2, Qingao Wei2

  • 1Cheeloo College of Medicine, Shandong University, No. 44 Wenhua West Road, Jinan, Shandong 250012, China; Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 Wenhua West Road, Jinan, Shandong 250012, China.

Cellular signalling
|February 22, 2026
PubMed
まとめ

新しい薬であるGNE-493は,N-アセチルトランスフェラーゼ10 (NAT10) を標的とし,グルコース代謝を阻害することによって胃がんの成長を抑制します. このアプローチは,化学抵抗性腫瘍に対する有望な効果を示しています.

キーワード:
化学抵抗性についてです.GNE-493 について胃がん 胃がん 胃がんグライコリシス (Glycolysis) とはac4Cアセチル化による

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