アンフィパスのN端のヘリキスは,進化を通して抗微生物ペプチドのようなメカニズムを通じてMLKL媒介性ネクロプトシスを駆動します

Xin Tian1, Xiaotong Jin1, Shuai Jiang1

  • 1State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266000, China; Laboratory for Marine Biology and Biotechnology,Qingdao Marine Science and Technology Center, Qingdao 266000, China; Laboratory of Experimental Marine Biology,Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266000, China; College of Earth and Planetary Sciences, University of Chinese Academy of Sciences, Beijing, China.

PubMed
まとめ

ネクロプトーシスはMLKLに依存しています.

関連する概念動画

Necrosis01:16

Necrosis

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The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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Transduction01:16

Transduction

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Antimicrobial Proteins01:23

Antimicrobial Proteins

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Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
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The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
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