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以前の持続したウイルス学的な応答を有する患者の間で遅いC型肝炎再発の進化: 18年間の見通し研究
Wei-Ting Chen1, Yi-Jyun Shen2, Rong-Nan Chien1
1Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Journal of global antimicrobial resistance
|February 22, 2026
まとめ
遅期のC型肝炎ウイルス (HCV) 再発 (RCI) は,持続性ウイルス学的応答 (SVR) を達成するアジア系患者ではまれである. 隠されたHCV感染 (OCI) は,RCIに先行し,ソフォスブビール/ヴェルパタスビールを用いて再治療を成功させる可能性があります.
科学分野:
- 肝臓病理学 肝臓病理学
- ウイルス学 ウイルス学 ウイルス学
- 感染症 感染症は感染症です.
背景:
- 後期再発性C型肝炎ウイルス (HCV) 感染症 (RCI) 現象型はアジアでは十分に理解されていません.
- 持続的なウイルス反応 (SVR) はHCV治療の目標ですが,遅い再発は起こりえます.
- 隠されたHCV感染 (OCI) は,後期的なRCIの潜在的な要因です.
研究 の 目的:
- SVR.を持つ台湾の患者における遅期のRCIのフェノタイプを調査する.
- 後期RCIの発生率とOCIとの関連性を決定する.
- RCIが遅れている患者の治療結果を評価する.
主な方法:
- 台湾のSVR患者1004人を対象とした18年間の前向きな研究.
- 3~6ヶ月に一度の定期的なフォローアップ,OCIの評価を含む.
- 肝臓酵素異常またはOCIを有する患者の遅期のRCI評価.
主要な成果:
- 531人中139人 (26.1%) の患者がOCI検査で陽性だった.
- 2人の患者 (0.19%) が18年間の追跡期間中に遅いRCIを発症した.
- 遅期のRCI患者には,肝硬変や肝細胞癌 (HCC) がありませんでした.
結論:
- 遅期のRCIは,アジア系SVR患者ではまれなイベントであり,症例の0.19%に発生します.
- Sofosbuvir/velpatasvirは,RCIが遅かった両方の患者で,第2のSVRを成功裏に達成しました.
- OCI,肝疾患,および遅期のRCIとの関係を明らかにするためにさらなる研究が必要である.
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