妄想における循環器機能不全:体系的なレビュー
J Reid Black1, Rachel E Landrum2, Emma O'Hagan3
1Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, United States of America.
Journal of the Academy of Consultation-Liaison Psychiatry
|February 22, 2026
まとめ
妄想は昼間の機能不全と関連しているが,その関係は複雑である. 明るい光の治療は予防に有望な結果を示しているが,他の介入は一貫していない結果をもたらし,さらなる研究が必要である.
科学分野:
- 神経科学は神経科学である.
- スリープ・メディシン (睡眠医学)
- ゲリアトリクス ゲリアトリクス
背景:
- 妄想症は,有意な罹病率を持つ一般的な神経精神病症候群である.
- 循環器の障害は,ますますデリリウムの中心的な特徴として認識されています.
- 昼間の機能不全と妄想の間の正確な関係は,十分に研究されていない.
研究 の 目的:
- サーカディアン機能障害と妄想の関係について,体系的に検討する.
- 妄想における昼夜障害の指標を特定するために.
- 妄想の進行に影響を与える介入と環境変数を評価する.
主な方法:
- PRISMAのガイドラインに沿った体系的なレビュー.
- 検索したPubMed,Embase,PsycINFO,Web of Scienceは2024年10月まででした.
- 英語でのヒト研究を含み,質的データを合成した.
主要な成果:
- 1908 件の記事のうち 58 件が掲載基準を満たした.
- アクティグラフィー,ポリソムノグラフィー,EEGにより,妄想における睡眠/循環器の違いが検出されました.
- 明るい光による治療は,妄想の予防に有望であることが示され,メラトナージック剤は不一致であった.
結論:
- 妄想と昼夜機能不全の関連は複雑で,完全に理解されていない.
- メラトニンやコルチゾールのような生理学的バイオマーカーは,妄想と矛盾した関連を示した.
- 戦略を導くために,マルチモダルの対策を備えた,より大規模で厳格な研究が必要である.
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