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Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Understanding Sleep01:11

Understanding Sleep

Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...

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Updated: May 10, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
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妄想における循環器機能不全:体系的なレビュー

J Reid Black1, Rachel E Landrum2, Emma O'Hagan3

  • 1Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, United States of America.

Journal of the Academy of Consultation-Liaison Psychiatry
|February 22, 2026
PubMed
まとめ

妄想は昼間の機能不全と関連しているが,その関係は複雑である. 明るい光の治療は予防に有望な結果を示しているが,他の介入は一貫していない結果をもたらし,さらなる研究が必要である.

キーワード:
サーカディアン機能不全は,サーカディアンリズム (昼夜リズム)コンサルティング・コネクション・精神医学デリリウム・デリリウム睡眠-覚醒サイクルシステマティック・レビュー

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科学分野:

  • 神経科学は神経科学である.
  • スリープ・メディシン (睡眠医学)
  • ゲリアトリクス ゲリアトリクス

背景:

  • 妄想症は,有意な罹病率を持つ一般的な神経精神病症候群である.
  • 循環器の障害は,ますますデリリウムの中心的な特徴として認識されています.
  • 昼間の機能不全と妄想の間の正確な関係は,十分に研究されていない.

研究 の 目的:

  • サーカディアン機能障害と妄想の関係について,体系的に検討する.
  • 妄想における昼夜障害の指標を特定するために.
  • 妄想の進行に影響を与える介入と環境変数を評価する.

主な方法:

  • PRISMAのガイドラインに沿った体系的なレビュー.
  • 検索したPubMed,Embase,PsycINFO,Web of Scienceは2024年10月まででした.
  • 英語でのヒト研究を含み,質的データを合成した.

主要な成果:

  • 1908 件の記事のうち 58 件が掲載基準を満たした.
  • アクティグラフィー,ポリソムノグラフィー,EEGにより,妄想における睡眠/循環器の違いが検出されました.
  • 明るい光による治療は,妄想の予防に有望であることが示され,メラトナージック剤は不一致であった.

結論:

  • 妄想と昼夜機能不全の関連は複雑で,完全に理解されていない.
  • メラトニンやコルチゾールのような生理学的バイオマーカーは,妄想と矛盾した関連を示した.
  • 戦略を導くために,マルチモダルの対策を備えた,より大規模で厳格な研究が必要である.