尿中のN-ニトロサミンに対する食事中ニトラートの影響を調べた臨床研究
Catherine P Bondonno1, Michaela L Sundqvist2, Sujata Shinde3
1Edith Cowan University; University of Western Australia.
The American journal of clinical nutrition
|February 22, 2026
まとめ
ダイエット中の窒素の摂取は,毎日限度を超えても,5週間にわたって尿中のN-ニトロサミンを増加させませんでした. この研究では,野菜やサプリメントから摂取するナイトレートが,N-ニトロサミンの形成に関して安全であることを示唆しています.
科学分野:
- 栄養科学 栄養学 栄養科学は,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学は,栄養学が,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は
- 毒理学 毒理学 毒理学
- 食品の安全性 食品の安全性について
背景:
- 食事中の無機窒素は,発がん性N-ニトロサミンへの潜在的変換により規制されています.
- 食品や飲料水の窒素濃度に関する懸念も存在します.
研究 の 目的:
- 尿中のN-ニトロサミンの排泄を5週間にわたって毎日の食中窒素摂取量に対応して評価する.
- 野菜経由の窒素投与と,窒素塩のサプリメントを比較する.
主な方法:
- 軽度の高血圧の231人の参加者はランダムに3つのグループに分けられた:低窒素野菜をプラセボで,低窒素野菜をナトリウム窒素で,または高窒素野菜をプラセボで.
- 尿中の窒素酸塩とN-ニトロサミンの濃度は,それぞれHPLCとUHPLC-MS/MSを用いて測定されました.
- 統計分析のためにペア化されたtテストが使用されました.
主要な成果:
- 尿中の窒素濃度は,窒素に富んだ野菜や,窒素酸カリウムを摂取したグループで著しく増加した.
- 尿経によるN-ニトロサミンの排泄量は低いままで,どのグループでも有意な変化はなかった.
- 個々のN-ニトロサミンの種については,有意な変化は見られなかった.
結論:
- 5週間の食事中ナイトレートの摂取は,許容可能な日用限度を超えても,尿中のN-ニトロサミンの排泄を増加させなかった.
- 植物源と食用窒素酸塩の窒素塩は,N-ニトロサミンの形成に関して安全であるように見えます.
- 研究結果は,食中の窒素に関する現在の規制が,N-ニトロサミンに関する懸念に関して過度に厳格である可能性があることを示唆しています.
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