小児肥満における腸-脳相互作用障害 (ローマIV):炎症マーカーとの流行と相関
Antonio Colucci1, Mara Creoli1, Giuseppina Rosaria Umano1
1Department of Woman, Child, General and Specialist Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
まとめ
腸-脳相互作用障害 (DGBIs) は,肥満の子供の3分の1以上に影響し,機能性便秘が最も一般的です. 変化した胆酸レベルと非アルコール性脂肪肝疾患は,この集団におけるDGBIsに関連しています.
科学分野:
- 小児胃腸内科 小児胃腸内科
- メタボリック障害 メタボリック障害
- 腸-脳研究軸の研究
背景:
- 肥満はますます腸-脳相互作用障害 (DGBIs) と関連付けられています.
- 炎症マーカーの変化は,肥満の個人に観察されています.
研究 の 目的:
- 肥満児におけるDGBIの罹患率を決定する.
- 肥満児のDGBIと不肥満児のDGBIの間の炎症マーカーの違いを調査する.
主な方法:
- 200人の肥満児 (BMI z-score > +2 SD) を対象とした横断的な研究.
- 評価されたDGBIsは,アンソポメトリー,ラボテスト,胆酸 (BA) レベルとともに,ローマIV基準を使用して評価されました.
- 非アルコール性脂肪肝疾患 (NAFLD) に対して評価されています.
主要な成果:
- 肥満児の36.5%が少なくとも1つのDGBIを患っており,最も一般的に機能性便秘 (70.4%) であった.
- DGBIは,特に青春期前の子供では,血清BA濃度の変化と有意に関連していました.
- DGBIを患った子供の41.1%はNAFLDも患っていた.
結論:
- DGBIは肥満児の間で高い頻度で,機能性便秘が最も一般的です.
- 変化したBAレベルとNAFLDは,DGBIsと強い関連性を示し,共通の代謝経路を示唆しています.
- これらの発見は,小児肥満におけるDGBIの将来の診断および治療戦略を参考にすることができます.
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