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Updated: Feb 24, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

非対称ジ（ヘテロアリール）メタンにアクセスするためのパラジウム触媒カスケード二重環化反応

Xing Cai¹, Huixuan Zhu¹, Xueli Feng¹

¹Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, China. junniz@whut.edu.cn.

Organic & biomolecular chemistry

|February 23, 2026

Abstract:

A palladium-catalyzed cascade double annulation reaction for the synthesis of unsymmetrical di(heteroaryl)methanes from non-heteroaryl substrates has been developed. This five-step cascade reaction integrates a furan ring and an indole/isoquinolinone scaffold into a methane molecule through η³-allylpalladium(II)-catalyzed cycloisomerization of β-chlorovinyl ketones followed by allylic heteroarylation, enabling the rapid construction of diverse heteroaryl units with a flexible methylene linker. Furthermore, initial screening indicated that compound 5fa exhibited potential antitumor activity in HeLa cells with the highest inhibition rate among the selected compounds.

キーワード:

パラジウム触媒カスケード反応ジ（ヘテロアリール）メタン合成医薬品化学抗腫瘍活性

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Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

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Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

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