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関連する概念動画

Overview of Protein Metabolism01:21

Overview of Protein Metabolism

4.2K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
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Metabolism of Chemolithotrophs01:15

Metabolism of Chemolithotrophs

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Chemolithotrophs are microorganisms that obtain energy by oxidizing inorganic molecules such as hydrogen gas (H₂), ammonia (NH₃), reduced sulfur compounds (H₂S, S²⁻), and ferrous iron (Fe²⁺). Unlike heterotrophic organisms that rely on organic carbon, chemolithotrophs transfer electrons from these inorganic donors to the electron transport chain (ETC), generating a proton motive force (PMF) that drives ATP synthesis through oxidative phosphorylation.
974
Overview of Metabolism01:40

Overview of Metabolism

39.3K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
39.3K
¹H NMR Chemical Shift Equivalence: Homotopic and Heterotopic Protons01:03

¹H NMR Chemical Shift Equivalence: Homotopic and Heterotopic Protons

4.2K
Protons in identical electronic environments within a molecule are chemically equivalent and have the same chemical shift. The replacement test is a useful tool to identify chemical equivalence and predict NMR spectra. A substituent replaces each of the protons being examined and the resulting molecules are compared. If the same molecule is obtained, the protons are equivalent or homotopic. Replacement of any hydrogens in ethane by chlorine yields chloroethane because all six protons are...
4.2K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

17.1K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
17.1K
¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons00:58

¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons

3.4K
Replacing each alpha-hydrogen in chloroethane by bromine (or a different functional group) yields a pair of enantiomers. Such protons are called prochiral or enantiotopic and are related by a mirror plane. Enantiotopic protons are chemically equivalent in an achiral environment. Because most proton NMR spectra are recorded using achiral solvents, enantiotopic hydrogens yield a single signal.
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
3.4K

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An Integrated Workflow of Identification and Quantification on FDR Control-Based Untargeted Metabolome
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全方位からの学習：メタボライトアノテーションのためのマルチビュー対照学習フレームワーク

Yan Zhou Chen1, Soha Hassoun1,2

  • 1Department of Computer Science, Tufts University, Medford, Massachusetts 02155, United States.

Analytical chemistry
|February 23, 2026
PubMed
まとめ

新しいフレームワークであるマルチビュープロジェクション（MVP）は、分子データとスペクトルデータを共同で分析することにより、メタボロミクスにおけるメタボライトの同定を強化します。このアプローチは、スペクトルアノテーションの精度を向上させ、疾患研究と創薬を前進させます。

キーワード:
メタボロミクススペクトルアノテーションマルチビュー学習対照学習分子構造質量分析計算化学バイオインフォマティクス

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A Strategy for Sensitive, Large Scale Quantitative Metabolomics
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Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis
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Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis

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関連する実験動画

Last Updated: Feb 24, 2026

An Integrated Workflow of Identification and Quantification on FDR Control-Based Untargeted Metabolome
05:35

An Integrated Workflow of Identification and Quantification on FDR Control-Based Untargeted Metabolome

Published on: September 20, 2022

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A Strategy for Sensitive, Large Scale Quantitative Metabolomics
14:18

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

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Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis
11:25

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis

Published on: July 11, 2014

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科学分野:

  • メタボロミクス
  • 計算化学
  • バイオインフォマティクス

背景:

  • 高スループット質量分析法を利用するメタボロミクスは、細胞生化学、疾患メカニズム、創薬、個別化医療の理解に不可欠です。
  • 測定されたスペクトルに分子構造を割り当てることの難しさによる低いスペクトルアノテーション率は、メタボロミクスにおける進歩を妨げています。

主な方法:

  • MVPは、対照的なマルチビュー学習を採用して、分子グラフ、分子フィンガープリント、スペクトル、およびコンセンサススペクトルといった多様なデータビュー間の相互情報を捉えます。
  • このフレームワークは、連結または補助タスクに基づいてきた以前の方法とは異なり、すべてのビューから共同で学習します。
  • MVPは、個々のスペクトルまたはコンセンサススペクトルのいずれかを使用した柔軟なアノテーションをサポートします。

結論:

  • MVPは、複数の分子/スペクトルデータビューから学習するための柔軟で拡張可能な基盤を提供します。
  • このフレームワークは、スペクトルアノテーションに関して既存の方法よりも優れた、または同等のパフォーマンスを示します。
  • MVPによって促進されるアノテーション率の向上は、メタボロミクス関連分野での発見を加速することができます。