地中海食および地中海式DASH食への異なる食事パターンの遵守と、全脳卒中、虚血性脳卒中、および出血性脳卒中のその後のリスク
Sara Castro-Barquero1,2,3, Eric B Rimm1,4,5, Tudor G Jovin6
1Department of Nutrition (S.C.-B., E.B.R., M.A.M.-G.), Harvard T.H. Chan School of Public Health, Boston, MA.
Stroke
|February 23, 2026
まとめ
地中海食および地中海式DASH食への遵守は、ハイリスク個人において脳卒中リスクを有意に低下させます。この研究は、これらの健康的な食習慣が全脳卒中および虚血性脳卒中に対して保護的な効果を持つことを強調しています。
科学分野:
- 心血管疫学
- 栄養科学
- 予防医学
背景:
- 食事パターンは心血管疾患(CVD)のリスクに影響を与えます。
- 脳卒中サブタイプに対する健康的な食事に関する前向きデータは限られています。
- この研究は、食事パターンと脳卒中発生率との関連性を調査します。
研究 の 目的:
- 4つの健康的な食事パターンの遵守と、全脳卒中および虚血性脳卒中のリスクとの関連性を将来的に検討すること。
- PREDIMED試験のハイリスク集団のデータを分析すること。
主な方法:
- PREDIMEDランダム化比較試験コホート(n=7447)の二次解析。
- 地中海食、DASH食、地中海式DASH食、およびプラネタリーヘルスダイエット指数の遵守状況の評価。
- 脳卒中リスクを決定するために多変量調整コックス比例ハザードモデルを使用しました。
主要な成果:
- 31,024人年以上で、135件の脳卒中が発生しました(虚血性112件、出血性23件)。
- 地中海食および地中海式DASH食への最も高い遵守率は、全脳卒中リスクの有意な低下と関連していました(それぞれハザード比0.26および0.25)。
- 虚血性脳卒中でも同様の低下が観察されました。DASH食またはプラネタリーヘルスダイエット指数との有意な関連はありませんでした。
結論:
- 地中海食および地中海式DASH食への遵守率の向上は、全脳卒中および虚血性脳卒中のリスク低下と関連しています。
- これらの発見は、CVDリスクの高い個人における脳卒中予防における特定の健康的な食事パターンの役割を支持しています。
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