NIR-IIイメージング誘導型複合光線力学療法の分子工学イオン性有機光線力学診断薬

¹College of Chemistry and Chemical Engineering, College of Green Chemistry and Environment, Institutes of Biomedical Sciences, Inner Mongolia Key Laboratory of Synthesis and Application of Organic Functional Molecules, Inner Mongolia University, Hohhot 010021, P. R. China. jiangguoyu@mail.ipc.ac.cn.

Chemical communications (Cambridge, England)

|February 23, 2026

Abstract:

We develop ionic small-molecule phototheranostics by molecular engineering of positive charges and hydrophilicity/hydrophobicity balance. The optimized agent, 2PyI, achieves balanced amphiphilicity, enabling efficient NIR-II emission, reactive oxygen species generation, and photothermal conversion. It facilitates high-resolution NIR-II imaging-guided synergistic photodynamic/photothermal therapy.

キーワード:

光線力学診断薬イオン性小分子 NIR-IIイメージング光線力学療法光熱療法がん治療

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