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Updated: Feb 24, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

観察薬物研究におけるグローバルな医薬品データ調和に向けたステップ：RxNorm拡張の開発

Anna Ostropolets^1,2, Aleh Zhuk³, Eduard Korchmar³

¹Columbia University, New York NY, United States.

AMIA ... Annual Symposium proceedings. AMIA Symposium

|February 23, 2026

Abstract:

This paper presents RxNorm Extension (RxE), a standardized drug vocabulary system designed to harmonize drug data across international databases. RxE integrates drugs from multiple national drug repositories, enhancing global drug safety and effectiveness research by standardizing drug representations in disparate drug vocabularies to a structure following RxNorm, a reference standard in the US. We developed an attribute-based mapping approach that improves consistency and reduce manual data processing. Based on 12 vocabularies included, we observe similar dose form and ingredient usage patterns but many more brand names available worldwide. The quality of RxE depends on the thorough examination of the source vocabulary, where challenges include discrepancies in brand names, poorly structured dosage forms, and faulty dosages. Despite the challenges, RxE has been used in numerous clinical and methodological studies. Future directions focus on expanding coverage, improving mapping automation, and fostering international collaboration to optimize global drug safety and effectiveness efforts.

キーワード:

RxNorm拡張医薬品データ調和グローバルな医薬品安全性観察薬物研究標準化された医薬品語彙

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