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一次性失眠患者在言语流畅性任务中左背外侧前额叶皮层的任务诱发性功能亢进：一项近红外光谱研究

Ting Wu¹, Hong He^1,2, Bo Yu¹

¹The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, China.

Frontiers in psychiatry

|February 23, 2026

まとめ

与良好睡眠者相比，原发性失眠患者在言语流畅性任务中表现出大脑左背外侧前额叶皮层激活增加，这表明存在独特的神经机制。

科学分野:

神经科学
认知心理学
医学成像

背景:

原发性失眠（PI）是一种普遍的睡眠障碍。
了解PI的神经基础对于有效治疗至关重要。
以往的研究探索了失眠症的大脑差异，但基于任务的激活研究较少见。

研究の目的:

研究原发性失眠（PI）患者与良好睡眠者（GSs）之间功能性大脑激活的差异。
在言语流畅性任务（VFT）期间使用功能性近红外光谱（fNIRS）评估认知表现和大脑活动。
确定原发性失眠的潜在神经关联。

主な方法:

招募了30名PI患者和30名健康的GS。
参与者完成了临床问卷调查，并在VFT期间接受了fNIRS扫描。
使用两样本t检验比较两组之间的大脑激活情况。

主要な成果:

PI组在VFT期间左背外侧前额叶皮层的大脑激活明显高于GS组（p < 0.05）。
这一发现表明原发性失眠患者在认知任务中前额叶皮层参与的改变。

結論:

该研究强调了PI患者在认知任务期间前额叶皮层激活的差异。
这些发现有助于理解与原发性失眠相关的神经机制。
需要进一步研究以探讨这些发现对诊断和治疗的意义。

キーワード:

功能性近红外光谱,功能亢进,前额叶皮层,原发性失眠,言语流畅性任务

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