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Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

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Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis EAE Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge
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マウスネオアンチゲン免疫原性比較のためのフレームワーク

Peter J Matulich, Carly N Sprague, Victoria P Schuster

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    |February 23, 2026
    PubMed
    まとめ
    この要約は機械生成です。

    がん免疫療法におけるネオアンチゲンの比較は重要である。ペプチド-MHC複合体の安定性は、前臨床モデルにおいて細胞傷害性CD8+ T細胞応答の有効性を予測する結合親和性よりも優れている。

    キーワード:
    がん免疫療法ネオアンチゲン免疫原性T細胞応答ペプチド-MHC安定性マウスモデル

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