関連する実験動画

Updated: Feb 24, 2026

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
07:33

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry

Published on: October 15, 2018

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タンパク質構造予測の改善：統合型クライオEMおよびイオン移動質量分析法モデリング

Jacob B Howard, Akshaya Narayanasamy, Steffen Lindert

    bioRxiv : the preprint server for biology
    |February 23, 2026
    PubMed
    まとめ

    本研究では、クライオ電子顕微鏡（cryo-EM）とイオン移動質量分析（IM-MS）データを組み合わせ、タンパク質構造予測の精度を大幅に向上させる新しい手法CRIMを紹介します。CRIMは、実験データが限られている場合に特に有効です。

    キーワード:
    タンパク質構造予測クライオ電子顕微鏡イオン移動質量分析構造生物学創薬CRIMRosetta原子座標低分解能データ計算生物学

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    Cryo-electron Microscopy01:28

    Cryo-electron Microscopy

    Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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