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Updated: Feb 24, 2026

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PNPLA2およびPNPLA3の膜ターゲティングのマルチスケール解析

Amit Kumar, Grace Teskey, Emilio Mottillo

    bioRxiv : the preprint server for biology
    |February 23, 2026
    PubMed
    まとめ

    Patatin様ホスホリパーゼドメイン含有タンパク質2（PNPLA2）およびPNPLA3は、異なる膜相互作用によって脂質代謝を調節します。それらのC末端ヘリックスは脂質小滴への結合を媒介し、酵素活性と細胞脂質貯蔵に影響を与えます。

    キーワード:
    PNPLA2PNPLA3脂質代謝膜結合酵素活性脂質小滴

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