力学的刺激に応答するハイドロゲルがPiezo1を介した食作用を活性化することにより糖尿病性創傷治癒を促進する

Correcting the disordered metabolism and achieving dynamic, comprehensive management of chronic diabetic wounds remains a significant challenge. This study presents a double-network dynamic hydrogel exhibiting long-term anti-inflammatory, antioxidant properties, and tunable mechanical strength. The hydrogel is primarily composed of modified chitosan, hyaluronic acid, sodium alginate, and ZnO₂/Fe³⁺ nanoparticles. The incorporated ZnO₂/Fe³⁺ nanoparticles enable microenvironmental regulation by responding to H⁺ or reactive oxygen species (ROS), while the released Fe³⁺ ions drive hydrogel network reconstruction, thereby enhancing mechanical properties. In vitro studies demonstrate the hydrogel's efficacy in efficiently scavenging ROS and enhancing Piezo1-mediated macrophage efferocytosis through cell-matrix interactions, accelerating macrophage polarization towards the M2 phenotype and resolving inflammation. In vivo experiments further confirm that the CHS@ZnO₂/Fe³⁺ hydrogel significantly promotes re-epithelialization. Mechanical stimulation provided by the hydrogel recruited abundant fibroblasts and endothelial cells to the wound site, facilitating collagen deposition and angiogenesis. This novel hydrogel dressing, combining mechanical and biochemical dual-regulation, provides an advanced therapeutic strategy for the efficient repair of diabetic chronic wounds.