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新規発症のチック障害とブプロピオンXLの関連:稀な症例報告
Ovais Rashid1,2,3, Priyanka Hooda1, Simranjeet Kaur1
1Centre of Excellence in Mental Health, Psychiatry, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. RML Hospital, New Delhi, IND.
Cureus
|February 23, 2026
まとめ
ノルエピネフリン・ドーパミン再取り込み阻害薬(NDRI)であるブプロピオンXLは、稀に新規発症のチックを引き起こす可能性があります。この症例報告では、ブプロピオン開始後に運動および音声チックを発症し、中止後に消失した患者の詳細を説明します。
科学分野:
- 神経科学
- 精神医学
- 薬理学
背景:
- チックは、突然の、速い、非律動的な運動または発声です。
- ブプロピオンXL(ノルエピネフリン・ドーパミン再取り込み阻害薬)は、うつ病および禁煙の適応があります。
- チックは、刺激薬またはSSRIとは異なり、ブプロピオンの稀な副作用です。
研究 の 目的:
- ブプロピオンXLに関連する新規発症のチックの稀な症例を報告すること。
- ブプロピオン誘発性チックに対する臨床的注意の重要性を強調すること。
主な方法:
- 27歳男性患者の症例報告。
- 患者は抑うつ症状に対してブプロピオンXLを開始しました。
- 運動および音声チックの発症が観察されました。
主要な成果:
- 患者は、手を叩く(運動)および口笛を吹く/笑う(音声)チックを発症しました。
- ブプロピオンXL中止後、チックは完全に消失しました。
- チック管理のために低用量のリスペリドンが開始されました。
結論:
- ブプロピオンXLは稀に新規発症のチックを誘発する可能性があります。
- 臨床家はこの副作用に注意する必要があります。
- ブプロピオンの中止とリスペリドンなどの薬剤による治療により、チックは消失する可能性があります。
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