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Updated: Feb 24, 2026

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Jiaqi Lin1,2, Ning Mao1,2, Zheng Wu1

  • 1Department of Neurology, The Second Hospital of Dalian Medical University, Dalian, Liaoning Province, China.

Journal of translational internal medicine
|February 23, 2026
PubMed
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No abstract available in PubMed .

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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