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Updated: Feb 24, 2026

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

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Published on: December 1, 2023

多発性硬化症患者におけるリツキシマブ誘発性血清病：症例報告と文献レビュー

Asmae Sikkal¹, Salma Ouahmane¹, Hicham El Otmani^1,2

¹Department of Neurology and Clinical Neurophysiological Explorations, Ibn Rochd University Hospital of Casablanca, Casablanca, MAR.

|February 23, 2026

Abstract:

Rituximab is a chimeric anti-CD20 monoclonal antibody that is becoming increasingly used in multiple sclerosis. In rare cases, rituximab may induce a delayed immune-mediated reaction such as rituximab-induced serum sickness. We report the case of a 49-year-old woman with multiple sclerosis who developed rituximab-induced serum sickness characterized by fever, diffuse rash, lymphadenopathy, and arthralgia nine days after her first rituximab infusion. We reviewed the number of cases in a literature review, discussing their characteristics and mechanisms and the implications for using alternative anti-CD20 monoclonal antibodies such as ocrelizumab or ofatumumab for the management of multiple sclerosis.

キーワード:

免疫複合体介在性過敏症反応多発性硬化症リツキシマブリツキシマブ誘発性血清病血清病

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Published on: December 15, 2011

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