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Updated: Feb 25, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

サブ最大心肺運動負荷試験を用いた横断的分析による、Duke Activity Status Index推定最大酸素摂取量における系統的過大評価バイアスの低減

Kamren Hollingsworth^1,2, Yiyu Zhao^1,2, Jean G Charchaflieh^1,2

¹From the Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut.

|February 23, 2026

Abstract:

The Duke Activity Status Index (DASI) overestimates peak VO2 compared to cardiopulmonary exercise testing (CPET). This study examined anthropometric/demographical differences in 226 participants >60 years old undergoing submaximal CPET (smCPET). Both sexes overestimated DASI versus smCPET-derived peak oxygen uptake (VO2; males: 5.9 ± 7.7 mL kg-1 min-1; females: 7.2 ± 7.1, P < .001), with no bias differences (P = .224). Body mass index (BMI) was a primary predictor (β = .295, P = .001), showing progressive overestimation: normal/underweight (4.9 ± 7.5 mL kg-1 min-1), overweight (4.3 ± 8.5), obese I (6.4 ± 6.5), obese II+ (9.2 ± 6). A correction factor was developed: VO2 corrected = 34.08 + 0.153 × DASIsum-0.382 × BMI-0.123 × age + 1.962 × (1 for males, 0 for females).

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