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Updated: Feb 25, 2026

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pHは腸内細菌のトリプトファン代謝を調節する

Julius E Brinck¹, Martin F Laursen¹, Mikael Pedersen¹

¹National Food Institute, Technical University of Denmark, Kgs Lyngby, Denmark.

NPJ biofilms and microbiomes

|February 23, 2026

まとめ

腸のpHは,トリプトファンの代謝産物の微生物の産生に大きく影響する. 腸内pHを下げることで,有害なインドルを減らし,有益な化合物を増加させ,慢性腎臓病 (CKD) の潜在的な治療戦略を提供することができます.

科学分野:

微生物学微生物学とは
人間の生理学人間生理学
メタボロミクスとは

背景:

腸内pHは,腸内微生物群の構成と活動に影響を与える重要な要因です.
腸内細菌はトリプトファンをインドール,インドール乳酸 (ILA),インドールプロピオニン酸 (IPA) を含む様々な化合物へと代謝します.
インドールはインドキシル硫酸 (IS) の前駆体であり,慢性腎疾患 (CKD) と関連しており,ILAとIPAは有益な健康効果を有しています.

研究の目的:

微生物のトリプトファン代謝産物に対する腸内pHの影響を調査する.
糞便のpH,トリプトファン代謝産物,およびそれらの健康上の影響,特にCKDに関連した関係を調査する.

主な方法:

2人のヒトコホートにおける糞便のpHとトリプトファンの代謝物の分析.
異なるpHレベルでのE. coliとC. sporogenesを用いたin vitro発酵実験.
pHに依存する遺伝子発現と代謝物質の生産を評価するための人間の糞便培養.

主要な成果:

便のpH,インドール,尿のIS.との間で正の相関が観察されました.
糞便のpHと有益な代謝産物であるILAおよびIPA.の間で否定的な相関が見られた.
低pH (5.5) は,E. coliのインドル産生を抑制し,tnaA遺伝子を抑制し,同時にC. sporogenes.による有益な代謝物産生を高めました.

結論:

腸内PHは,腸内細菌のトリプトファン代謝の重要な調節剤として作用する.
腸内pHを調節することで,腸内微生物代謝物のバランスを変化させることで,CKDの管理のための潜在的な治療方法を示します.

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