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Updated: Feb 25, 2026

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テロメア重複を含むRNAのG四重複体は,ZBP1媒介の細胞死を引き起こす

Geng Qin1,2,3, Chuanqi Zhao1,2, Chengming Gao4

  • 1Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, PR China.

Nature communications
|February 23, 2026
PubMed
まとめ

Z-DNA結合タンパク質1-S (ZBP1-S) は,テロメア重複を含むRNA (TERRA) のG四重複体を感知し,炎症性細胞死を引き起こす. G4固有のリガンドは,この相互作用をブロックし,ZBP1-S媒介の免疫信号伝達を阻害します.

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