腹部外科手術を受けるがん患者のマルチモダルのリハビリテーションプログラム後の機能能力と身体構成の変化
Luuk D Drager1, Baukje van den Heuvel2, Dieuwke Strijker2
1Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands. Luuk.drager@radboudumc.nl.
Annals of surgical oncology
|February 23, 2026
まとめ
前期リハビリテーションは,腹部外科手術を受けるがん患者の機能能力と体調を大幅に改善しました. しかし,これらの得点は,手術後の長期間にわたって維持されず,継続的なサポートの必要性を強調しました.
科学分野:
- 腫瘍学 腫瘍学
- 運動生理学 運動生理学
- 外科手術の結果について
背景:
- 術前機能能力と身体構成は,がん患者の手術結果に影響します.
- 長期的効果と,予行リハビリテーションの運動量-反応は不明である.
研究 の 目的:
- 予備リハビリテーション中のおよび後の機能能力および体組成の変化を調査する.
- 腹部がん手術を受ける患者の運動用量反応関連性を評価する.
主な方法:
- F4S PREHAB試験 (2021年3月~2024年4月) の816人の患者が,がんのために選択的な腹腔外科手術を受けた.
- 機能能力 (ピーク酸素摂取量,運動能力,筋肉の強さ) と身体構成は,ベースライン,前期リハビリテーション後,手術後の3ヶ月で評価されました.
- 線形混合モデルを使用して,時間経過の変化と投与量反応関連性を分析しました.
主要な成果:
- ピーク酸素摂取量,運動能力,筋肉の強さ,体重,脂肪フリー質量において,予備リハビリテーション後の有意な改善が見られた.
- 機能能力の測定値は,手術後のベースライン値に戻ったか,またはベースライン値を下回った.
- 腫瘍の種類,ネオアジュバント療法,栄養失調のリスク,および遵守によって異なる運動用量反応関連が発見されました.
結論:
- 予備リハビリテーションは,腹部がん手術患者の機能能力と体調を向上させます.
- これらの改善は,通常,手術後の状態では持続しません.
- 将来の研究は,標的型アプローチと,手術後のリハビリテーション戦略との統合を探求すべきである.
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