ホスト-ゲスト化学を介した自己集合無機ナノキャリアによるがん治療の促進

Inorganic nanocarriers (INCs) have been widely used in drug delivery systems due to their excellent biocompatibility, ease of synthesis and functionalization, cost-effectiveness, and robust physicochemical stability. However, small-sized INCs are prone to rapid in vivo clearance, resulting in low accumulation and limited retention in target tissues or cells, significantly reducing their therapeutic efficacy. The self-assembly of small INCs into large aggregates represents an innovative approach for enhancing their tumor-specific accumulation and retention. This review primarily focuses on the stimuli-responsive self-assembly of INCs, including gold nanoparticles, calcium carbonate nanoparticles, ferroferric oxide nanoparticles, and silica nanoparticles, driven by supramolecular host-guest interactions. Specifically, this strategy aims to increase accumulation concentrations, prolong retention time, and achieve precise spatiotemporal control over drug release for tumor treatment. Thus, this review provides a critical summary and reference for exploring supramolecular host-guest interactions in drug delivery systems and promotes the advancement of supramolecular chemistry as an emerging interdisciplinary field.