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Updated: Feb 25, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

肥大型心筋症における自発性心筋障害：微小血管機能障害および微小血管閉塞の併存

Maethas Panyawongkhanti^1,2, Nonthikorn Theerasuwipakorn^1,3, Apichai Khongphatthanayothin^4,5

¹Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.

Radiology case reports

|February 24, 2026

Abstract:

Hypertrophic cardiomyopathy (HCM) is a genetic disorder characterized by left ventricular hypertrophy without abnormal loading conditions, often complicated by microvascular dysfunction (MVD), which leads to myocardial ischemia. While MVD in HCM has been extensively described, reports of concomitant microvascular obstruction (MVO) as a feature of spontaneous myocardial injury are scarce. We present a 58-year-old man with genetically confirmed HCM who experienced recurrent chest discomfort attributed to spontaneous myocardial injury. This was evidenced by markedly elevated biomarkers and cardiac magnetic resonance imaging (CMR) findings, including severe inducible myocardial ischemia on stress perfusion, myocardial edema, and MVO. This case highlights the potential coexistence of MVD and MVO in severe HCM, suggesting a complex interplay that may contribute to disease progression. Advanced imaging techniques, particularly CMR, are crucial in detecting myocardial damage and guiding management. Future research should explore the clinical significance of MVO in HCM and its potential as a therapeutic target.

キーワード:

心臓磁気共鳴画像法肥大型心筋症微小血管機能障害微小血管閉塞

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Real-time Pressure-volume Analysis of Acute Myocardial Infarction in Mice

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