小児急性リンパ芽球性白血病における侵襲性酵母感染症:多国籍臨床試験AIEOP-BFM ALL 2009からの報告
Andreas H Groll1, Simone Cesaro2, Julia Alten3
1Infectious Disease Research Program, Department of Pediatric Hematology and Oncology and Center for Bone Marrow Transplantation, University Children's Hospital Münster, Münster, Germany.
British journal of haematology
|February 24, 2026
Abstract:
Prospective data of a large randomized multi-international leukaemia trial revealed an incidence of 1.1% of invasive yeast infections (IYIs) in children with acute lymphoblastic leukaemia. IYIs occurred predominantly during induction chemotherapy, presented as bloodstream infection ± tissue involvement, were due to a variety of yeast and had an attributable mortality of 5.9%.
関連する概念動画
Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...


