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Updated: Feb 26, 2026

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Published on: November 26, 2019

集団ベースの構造的証拠：歯周炎、うつ病、生物学的老化が認知機能に及ぼす三者間の影響

Dawei Zhang, Shijie Zhu, Zhaobiao Zong

|February 24, 2026

要旨

Introduction:

Cognitive impairment represents critical public health challenges in aging societies. This study investigates periodontitis, depression, and biological aging's triadic effects on cognition.

Methods:

Structural equation modeling (SEM) and relative weight analysis (RWA) were applied to analyze data from 2011-2014 National Health and Nutrition Examination Survey (NHANES) (N=1,816). Cognitive function, periodontitis, depression, and biological age (PhenoAge) were assessed with covariates adjustment.

Results:

SEM revealed periodontitis severity, depressive symptoms, and PhenoAge advancement exhibited significant direct associations with lower cognitive performance after covariate adjustment. Simultaneously, biological aging partially mediated the influence of both depression and periodontitis on cognitive outcomes. RWA showed dominated cognitive variance, while periodontitis, depression and PhenoAge contributed significantly.

Conclusions:

This confirms triadic interdependencies where biological aging partially mediates periodontitis/depression effects on cognition. Prioritizing periodontal care and mental health may mitigate cognitive decline, especially in low-resource settings.

キーワード:

歯周炎うつ病生物学的老化認知機能加齢構造方程式モデリング疫学

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Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

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