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Updated: Feb 26, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

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Published on: December 21, 2019

メソテリオーマの局在は、腫瘍微小環境と前臨床モデルにおける免疫チェックポイント療法の反応に影響を与える

M Lizeth Orozco Morales^1,2,3, Sally M Lansley⁴, Wee Loong Chin³

¹School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.

Scientific reports

|February 24, 2026

まとめ

No abstract available in PubMed .

キーワード:

解剖学的局在免疫チェックポイント療法中皮腫腫瘍微小環境

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Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

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The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...