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Updated: Aug 7, 2026
Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment
Published on: November 22, 2024
腹部肥満被験者における16S rRNAシーケンシングに基づく鍼治療と漢方薬の併用療法による腸内細菌叢の改善：ランダム化比較試験
Yuan Menghua1, Shao Jianbin2, Yang Yawei3
1Department of Encephalopathy, Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China.
Objective:
To investigate Acupuncture-herb therapy modulates gut microbiota in abdominal obesity.
Methods:
A randomized controlled trial was designed in accordance with standard protocols. Abdominally obese subjects were randomized into four groups: A2 (Control): double placebo, A1 (Needle): press needle + placebo herb, A3 (herb): herbal medicine (Huatan Lishi Fang) + placebo needle, A4 (Combination): press needle + herbal medicine. After 12 weeks of treatment, groups were relabeled B1-B4. Weight, waist circumference, and body mass index were measured monthly. Gut microbiota was analyzed via 16S rRNA sequencing for diversity and abundance.
Results:
Combined needle-herb therapy significantly reduced waist circumference (P < 0.05). All treatments altered gut microbiota composition. The combination group showed significant changes in diversity (Chao1, Shannon, Simpson; P < 0.05). Needle therapy increased Bacteroidia; herbs reduced Lachnospiraceae and Megamonas. All results were significant (P < 0.05).
Conclusion:
Combined needle-herb treatment modulated 25 key gut flora across multiple taxonomic levels in abdominal obesity. It reduced Firmicutes and Bacteroidota. Bacteroidota, Actinobacteriota, and Prevo-tellaceae may suppress obesity, whereas Proteobacteria, Lachnospiraceae, and Megamonas may promote it. The combination specifically altered Bacteroidaceae, Lachno-spiraceae, Bacteroidia, and Megamonas.
