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Updated: Jun 9, 2026

Visualizing Non-lytic Exocytosis of Cryptococcus neoformans from Macrophages Using Digital Light Microscopy
10:02

Visualizing Non-lytic Exocytosis of Cryptococcus neoformans from Macrophages Using Digital Light Microscopy

Published on: October 21, 2014

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HBMECにおけるクリプトコッカス感染時の宿主病原体相互作用の統合的超微細構造およびトランスクリプトーム解析：予備的研究

Priya Krishnan1, Gautham Arunachal Udupi2, Rashmi Santhoshkumar3

  • 1Dept of Neuromicrobiology, National Institute of Mental Health and Neuro Sciences, Institute of National Importance, Bengaluru, India.

Frontiers in cellular and infection microbiology
|February 25, 2026
PubMed
まとめ

クリプトコッカスは血液脳関門（BBB）を破壊することで真菌性髄膜炎を引き起こす。本研究では、臨床分離株と環境分離株の両方で同様の侵入メカニズムと宿主応答が明らかになり、新しい抗真菌療法を開発するのに役立つ。

キーワード:
HBMEC血液脳関門クリプトコッカス髄膜炎遺伝子発現差デュアルRNAseq宿主病原体相互作用侵入透過型電子顕微鏡

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関連する概念動画

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...