高齢患者におけるレボフロキサシン耐性ストレプトコッカス・ゴードニイ感染性心内膜炎の1例:症例報告
Taiki Nishiba1, Kazuhisa Yokota2
1Internal Medicine, Mie Prefectural Shima Hospital, Shima, JPN.
Cureus
|February 25, 2026
まとめ
高齢者の感染性心内膜炎は診断が困難な場合があります。レボフロキサシン耐性菌によるこの重篤な感染症の管理には、抗菌薬投与前の迅速な血液培養と良好な口腔衛生が不可欠です。
科学分野:
- 感染症; 心臓病学; 老年医学
背景:
- 高齢者の感染性心内膜炎(IE)は、しばしば微妙な症状を呈し、診断の遅れにつながる。診断検査前の経験的抗菌薬の使用は、IEの認識をさらに複雑にする可能性がある。口腔衛生不良は、菌血症およびIEの潜在的な危険因子である。
研究 の 目的:
- 高齢患者におけるレボフロキサシン耐性ストレプトコッカス・ゴードニイによるIEの症例を記述する。高齢者におけるIEの診断および管理上の課題を強調する。抗菌薬投与前の血液培養と口腔衛生の重要性を強調する。
主な方法:
- IEの90代女性の症例報告。診断のために血液培養、心エコー検査、脳MRIを使用した。抗菌薬感受性試験によりレボフロキサシン耐性が特定された。
主要な成果:
- 患者は持続的な発熱を呈し、レボフロキサシン耐性S. gordoniiによるIEと診断された。心エコー検査では重度の大動脈弁逆流が認められた。MRIでは複数の塞栓性梗塞が明らかになった。適切な治療にもかかわらず、患者の状態は悪化し、緩和ケアにつながった。
結論:
- 抗菌薬投与前の血液培養の実施失敗と口腔衛生不良は、高齢者のIE診断における重大な課題である。早期の血液培養は、診断の遅れを避けるために不可欠である。口腔衛生を維持することは、IE関連菌血症のリスクを低減する可能性がある。
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