次世代ナレッジディスカバリー法を用いたトランスクリプトームデータに基づく重症アルツハイマー病の分子メカニズムの解明
Hind A Alkhatabi1, Alaa G Alahmadi2, Muhammad Imran Naseer3
1Dr. Hind A. Alkhatabi, Ph.D. Department of Biological Science, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
Pakistan journal of medical sciences
|February 25, 2026
まとめ
本研究は、重症アルツハイマー病（AD）における主要な分子経路を明らかにし、神経炎症とエネルギー代謝の障害を強調する。これらの知見は、ADの診断と治療法の改善に貢献する。
さらに関連する動画
関連する概念動画
01:26Alzheimer's Disease: Overview
1.9K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.9K
01:22Alzheimer's Disease: Treatment
1.1K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.1K