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Updated: Feb 26, 2026

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
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正常圧水頭症における安定同位体動態を用いた脳脊髄液タンパク質クリアランス障害の解明

Claire A Leckey1,2, Tatiana A Giovannucci1,2, Eimear C Murphy1

  • 1Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.

Brain communications
|February 25, 2026
PubMed
まとめ

正常圧水頭症（NPH）では脳脊髄液（CSF）タンパク質クリアランスが障害されている。新規の安定同位体標識法により、NPH患者ではトランスサイレチンのクリアランスが著しく遅いことが明らかになり、CSF流動の新たな診断およびモニタリングツールとなる可能性が示唆される。

キーワード:
認知認知症神経外科

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