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乳がんにおける分子および機能的プロファイリング:遺伝性および散発性症例への影響

Alessandra Virga1, Michela Cortesi1, Sara Bravaccini2

  • 1Biosciences Laboratory, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) "Dino Amadori", Meldola, Italy.

Frontiers in oncology
|February 25, 2026
PubMed
まとめ

No abstract available in PubMed .

キーワード:
乳がん機能解析遺伝性乳がん卵巣がん分子特性評価次世代シーケンシング散発性乳がん

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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Such genes that act...
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