2型糖尿病における味覚知覚の変化：味覚閾値と血糖コントロールに関する症例対照研究
Julika De1, Hina Handa1, Gaurav Arya1
1People's (Deemed to be University), People's Dental Academy, Department of Oral Medicine and Radiology, Bhanpur, Bhopal, 462037, Madhya Pradesh, India.
Journal of oral biology and craniofacial research
|February 25, 2026
まとめ
2型糖尿病（T2DM）は、特に甘味、酸味、苦味の味覚知覚を著しく損ないます。この味覚機能障害は血糖コントロール不良で悪化し、糖尿病管理の改善のために食事指導が必要になる場合があります。
科学分野:
- Endocrinology; Neuroscience; Nutrition Science
背景:
- Diabetes Mellitus (DM) is linked to altered taste perception, potentially causing cravings for carbohydrates.
研究 の 目的:
- To assess and characterize gustatory function in patients diagnosed with Type 2 Diabetes Mellitus.
主な方法:
- A cohort of 138 participants, including 46 with controlled T2DM, 46 with uncontrolled T2DM, and 46 healthy controls, was recruited.
主要な成果:
- HbA1c levels differed significantly across groups: uncontrolled T2DM (11.22%), controlled T2DM (7.43%), and controls (5.08%).
- Significant taste impairment was observed in T2DM patients, particularly for sweet, sour, and bitter tastes, worsening with poorer glycemic control (p < 0.001).
- Salt perception remained unaffected in individuals with T2DM (p = 0.56).
結論:
- Individuals with T2DM exhibit notable taste dysfunction, affecting sweet, sour, and bitter taste perception.
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