放射線療法後の混合表現型急性白血病を伴う二次性慢性骨髄性白血病の芽球期：症例報告

A 55-year-old woman underwent hysterectomy and pelvic radiation for cervical cancer, which remains in remission. Forty-three months later, she developed secondary CML-BP with CD19+ mixed phenotype (B/myeloid), previously unreported. Following induction therapy, sequential therapy with blinatumomab and ponatinib achieved qualitatively PCR-negative minor BCR::ABL1 transcripts, indicating that residual transcripts below the qualitative assay's detection limit were undetectable. She received an allogeneic bone marrow transplant and remains well with PCR-negative minor BCR::ABL1 at 15 months after transplantation. This sequential therapy suggests a potential utility as a bridge to hematopoietic stem cell transplantation for secondary CML-BP with CD19+ mixed phenotype.