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Updated: Feb 26, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

テルペノイド生合成における環縮小および環拡大反応と全合成への応用

Nicolas Kratena¹, Nicolas Heinzig¹, Peter Gärtner¹

¹Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9, A-1060, Vienna, Austria.

Beilstein journal of organic chemistry

|February 25, 2026

Abstract:

Terpenoids exhibit remarkable structural diversity, including highly complex ring-expanded or contracted carbocyclic skeletons. This review aims to explore intriguing examples of such ring-size alterations in all aspects of terpenoid synthesis. The current state-of-the-art regarding proposed biosynthetic pathways for terpenoids with unusual carbon skeleta, occurring either during initial cyclisation or subsequent oxidative tailoring, will be examined and discussed. Where possible, biogenetic relationships of closely related families of natural products will be contextualised by showing the mechanistic rationale for their interconversion. In the second part of this article, the application of bioinspired ring contraction and ring-expansion strategies in relevant natural product syntheses will be presented, demonstrating how synthetic chemistry can help to elucidate plausible biogenetic routes for structurally complex natural products.

キーワード:

生合成転位環縮小環拡大骨格編集テルペノイド全合成

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