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Updated: Feb 26, 2026

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COPD喫煙者に対する動機づけ面接と空気清浄機（MOVE）：無作為化二重盲検プラセボ対照試験

Nadia N Hansel^1,2, Nirupama Putcha¹, Han Woo¹

¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, United States.

American journal of respiratory and critical care medicine

|February 25, 2026

要旨

Rationale:

Indoor particulate matter (PM) is linked to worse respiratory outcomes in adults with chronic obstructive pulmonary disease (COPD). It is unclear if reducing indoor pollutants can improve respiratory health among current smokers.

Objective:

This study aimed to assess whether a multi-component environmental intervention to improve home air quality (PM and secondhand smoke (SHS) exposure) improves respiratory morbidity among current smokers with COPD.

Methods:

Current smokers with moderate-to-severe COPD were randomized to receive active portable HEPA air cleaners and motivational interviewing (MI) for PM and SHS reduction, respectively; or sham air cleaners without MI. The primary outcome was six-month change in Saint George's Respiratory Questionnaire (SGRQ). Secondary outcomes were respiratory symptoms, exacerbation risk, and lung function.

Main Results:

Among 121 randomized participants, 99 completed the study. The active intervention resulted in reduced PM levels compared to control, but no reduction in indoor SHS exposure. Those in the active arm showed a clinically and statistically significant improvement in total SGRQ score compared to control (ß -4.4 [95% CI, -8.2 to -0.5]; P = 0.025). Secondary analyses indicated significant improvement in respiratory symptoms (dyspnea and cough) and health status as measured by COPD Assessment Test and clinical COPD questionnaire among the active group (vs. control). There was no significant difference in FEV1 change, sputum symptoms or odds of exacerbations between groups.

Conclusions:

This study is the first to demonstrate potential health benefits from an environmental intervention in active smokers with COPD, most likely attributable to PM reduction associated with portable HEPA air cleaner use.

キーワード:

空気清浄機慢性閉塞性肺疾患環境粒子状物質

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