Sophora tonkinensis 根由来の抗糖尿病ポリフェノール化合物、6/6/7/6/5 環系を特徴とする 2 つのユニークな二量体を含む

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Updated: Feb 26, 2026

Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis

Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis

Published on: August 15, 2025

Xu Zhang¹, Jiang Li¹, Xiao-Yun Yan¹

¹State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Journal of natural products

|February 25, 2026

Abstract:

Two unique polyphenolic compounds featuring a 6/6/7/6/5 fused skeleton, sotodisoflavanones A and B (1 and 2), and two novel 2-arylbenzofuran dimers shandougenines C and D (3 and 4) were isolated from the roots of Sophora tonkinensis. Their structures were elucidated through spectroscopic analysis and quantum chemical calculations. Compounds 1 and 5-7 showed significant PTP1B inhibition (IC₅₀ = 2.70 ± 0.50, 0.88 ± 0.17, 2.70 ± 0.50, 1.90 ± 0.40 μM, respectively) and enhanced insulin sensitivity by promoting HepG2 cell glucose consumption.

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Sophora tonkinensis polyphenols dimers PTP1B inhibitors insulin sensitivity diabetes natural products

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Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

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